RAET1E

Alternative Names: bA350J20.7, LETAL, N2DL-4, NKG2DL4, RAET1E2, RL-4, ULBP4, NKG2D ligand 4, Retinoic acid early transcript 1E, RAE-1-like transcript 4, Lymphocyte effector toxicity activation ligand, UNQ1867/PRO4303.

RAET1E is a member of the MHC class I family, which consists of genes located in a cluster on chromosome 6q24.2-q25.3. Unlike other RAET1 proteins, RAET1E and RAET1G have type I membrane-spanning sequences at their C termini instead of glycosylphosphatidylinositol anchor sequences. RAET1E, acting as a ligand for the NKG2D receptor expressed on various immune cells, plays a role in both innate and adaptive immune responses. It stimulates NK cells and enhances tumor immune surveillance by promoting the growth of cytotoxic lymphocytes that target tumors.

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  • Sku: PSB-pro-1293-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Retinoic Acid Early Transcript 1E (RERAT1E) is a protein encoded by the RERAT1E gene and belongs to the retinoic acid receptor (RAR) family. RARs are nuclear receptors that play a crucial role in cellular differentiation, development, and homeostasis. RERAT1E has a molecular weight of approximately X kilodaltons (kDa) and is involved in regulating gene expression and cellular processes associated with retinoic acid signaling pathways. Understanding the functional implications of RERAT1E can provide valuable insights into the intricate mechanisms underlying retinoic acid-mediated biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.9 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation RAET1E protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMHSLCFN FTIKSLSRPG QPWCEAQVFL NKNLFLQYNS DNNMVKPLGL LGKKVYATST WGELTQTLGE VGRDLRMLLC DIKPQIKTSD PSTLQVEMFC QREAERCTGA SWQFATNGEK SLLFDAMNMT WTVINHEASK IKETWKKDRG LEKYFRKLSK GDCDHWLREF LGHWEAMPEP TVSPVNASDI HWSSSSLPD.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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RAET1E
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