PVR

Alternative Names: CD155, NECL-5, Nectin-like protein 5, PVR, PVS, Poliovirus receptor

The poliovirus receptor (PVR) is a transmembrane glycoprotein of the immunoglobulin superfamily. It plays a crucial role in modifying the virus structure and facilitating its interaction with the cell membrane. Additionally, PVR is involved in regulating helper T cell differentiation and allergic diseases. It is widely expressed in human cells and has diverse functions. PVR also holds potential as a biomarker for cancer development and progression, particularly in pancreatic cancer, where it plays important immunological and non-immunological roles.

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  • Sku: PSB-pro-2463-1µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Poliovirus Receptor is a protein that plays a crucial role in the cellular entry of poliovirus. Belonging to the immunoglobulin superfamily, this receptor facilitates the attachment and internalization of the virus into host cells, enabling viral replication. With a molecular weight of approximately 35 kilodaltons, this receptor is composed of three immunoglobulin-like domains that mediate the specific interaction with the viral capsid protein. Understanding the structure and function of Recombinant Human Poliovirus Receptor is of great significance in elucidating the mechanisms of poliovirus infection and developing potential antiviral strategies.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 90.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
36.1 kDa
Structure Contact for Details
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation PVR protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

WPPPGTGDVV VQAPTQVPGF LGDSVTLPCY LQVPNMEVTH VSQLTWARHG ESGSMAVFHQ TQGPSYSESK RLEFVAARLG AELRNASLRM FGLRVEDEGN YTCLFVTFPQ GSRSVDIWLR VLAKPQNTAE VQKVQLTGEP VPMARCVSTG GRPPAQITWH SDLGGMPNTS QVPGFLSGTV TVTSLWILVP SSQVDGKNVT CKVEHESFEK PQLLTVNLTV YYPPEVSISG YDNNWYLGQN EATLTCDARS NPEPTGYNWS TTMGPLPPFA VAQGAQLLIR PVDKPINTTL ICNVTNALGA RQAELTVQVK EGPPSEHSGM SRNLEHHHHH H

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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PVR

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