PTPRN

Alternative Names: Receptor-type tyrosine-protein phosphatase-like N, R-PTP-N, Islet cell antigen 512, ICA 512, Islet cell autoantigen 3, PTP IA-2, PTPRN, ICA3, ICA512.

Protein Tyrosine Phosphatase Receptor Type N (PTPRN) is an inactive protein that is heavily targeted by the autoimmune response in diabetes mellitus. The large intracellular tail at the end of the protein contains most of the epitopes that the autoantibodies bind to. PTPRN can be found in neural, neuroendocrine, and pancreatic islet cells.

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  • Sku: PSB-enz-1162-50µg
  • Vendor: ProSpec-Tany
$600.00 USD
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Title

Product Details

Product Description

Recombinant Human Protein Tyrosine Phosphatase Receptor Type N (PTPRN) is a member of the protein tyrosine phosphatase (PTP) family, which plays a critical role in regulating cellular signaling pathways. PTPRN is a transmembrane glycoprotein that is predominantly expressed in neuronal tissues, where it modulates neuronal development, synaptic plasticity, and neurotransmitter release. With a molecular weight of approximately 190 kDa, PTPRN functions as a receptor for extracellular matrix proteins and is involved in cell adhesion and migration processes. Understanding the biochemical properties and functional mechanisms of PTPRN can provide valuable insights into the intricate signaling networks underlying neuronal physiology and pathology.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Insect cells
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation PTPRN is supplied in 50mM Sodium phosphate (pH 8.0) and 20% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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PTPRN

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