PTGR1

Alternative Names: Prostaglandin reductase 1, PTGR1, PRG-1, 15-oxoprostaglandin 13-reductase, PGR1, NADP-dependent leukotriene B4 12-hydroxydehydrogenase, LTB4DH, ZADH3.

PTGR1 is an enzyme belonging to the NADP-dependent oxidoreductase L4BD family. It plays a key role in the metabolic inactivation of leukotriene B4 by converting it into its less active form, 12-oxo-leukotriene B4. PTGR1 is predominantly found in high levels in the kidney, liver, and intestine, with minimal presence in leukocytes.

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  • Sku: PSB-enz-633-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Prostaglandin Reductase 1 is an enzyme that belongs to the aldo-keto reductase family. With a molecular weight of approximately 35 kDa, this enzyme plays a key role in the metabolism of prostaglandins by catalyzing the reduction of prostaglandin E2 to prostaglandin F2α. Recombinant Human Prostaglandin Reductase 1 is commonly used in research settings to study the physiological and pathological roles of prostaglandins in various biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
38.6 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The PTGR1 solution (0.5mg/ml) contains 20mM Tris-HCl buffer, pH7.5, 10% glycerol, 1mM DTT and 200mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSEFMVRTK TWTLKKHFVG YPTNSDFELK TAELPPLKNG EVLLEALFLT VDPYMRVAAK RLKEGDTMMG QQVAKVVESK NVALPKGTIV LASPGWTTHS ISDGKDLEKL LTEWPDTIPL SLALGTVGMP GLTAYFGLLE ICGVKGGETV MVNAAAGAVG SVVGQIAKLK GCKVVGAVGS DEKVAYLQKL GFDVVFNYKT VESLEETLKK ASPDGYDCYF DNVGGEFSNT VIGQMKKFGR IAICGAISTY NRTGPLPPGP PPEIVIYQEL RMEAFVVYRW QGDARQKALK DLLKWVLEGK IQYKEYIIEG FENMPAAFMG MLKGDNLGKT IVKA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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PTGR1

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