PTGDS

Alternative Names: Not Available

ALDH2 is an enzyme in the aldehyde dehydrogenase family responsible for converting acetaldehyde to acetic acid. It is the second enzyme in the main pathway of alcohol metabolism. There are two liver isoforms of ALDH2: cytosolic and mitochondrial, differing in properties and localization. The majority of Caucasians have both isoforms, while about half of Orientals only have the cytosolic isoform. This absence of the mitochondrial isoform in Orientals contributes to their higher susceptibility to acute alcohol intoxication compared to Caucasians. ALDH2 has a low Km for acetaldehydes and is found in the mitochondrial matrix.

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  • Sku: PSB-enz-109-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Prostaglandin D2 Synthase is an enzyme belonging to the lipocalin family, responsible for the synthesis of prostaglandin D2 from prostaglandin H2. With a molecular weight of approximately 30 kDa, this enzyme plays a crucial role in the regulation of inflammation and allergic responses. Recombinant Human Prostaglandin D2 Synthase is widely used in research and pharmaceutical applications for its ability to modulate lipid mediator pathways and its potential therapeutic implications in various inflammatory conditions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95 % by SDS-PAGE
Activity
Specific activity is > 180 pmol/min/ug, and was obtained by measuring the increase of NADH in absorbance at 340 nm resulting from the reduction of NAD at pH 8.0 at 25C.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
56.8 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ALDH2 Mouse protein (0.5mg/ml) is formulated in Phosphate buffered saline (pH7.4), 20% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSSAAATSA VPAPNHQPEV FCNQIFINNE WHDAVSRKTF PTVNPSTGEV ICQVAEGNKE DVDKAVKAARAAFQLGSPWR RMDASDRGRL LYRLADLIER DRTYLAALET LDNGKPYVIS YLVDLDMVLK CLRYYAGWAD KYHGKTIPID GDFFSYTRHEPVGVCGQIIP WNFPLLMQAW KLGPALATGN VVVMKVAEQT PLTALYVANL IKEAGFPPGV VNIVPGFGPT AGAAIASHEG VDKVAFTGSTEVGHLIQVAA GSSNLKRVTL ELGGKSPNII MSDADMDWAV EQAHFALFFN QGQCCCAGSR TFVQENVYDE FVERSVARAK SRVVGNPFDSRTEQGPQVDE TQFKKILGYI KSGQQEGAKL LCGGGAAADR GYFIQPTVFG DVKDGMTIAK EEIFGPVMQI LKFKTIEEVV GRANDSKYGLAAAVFTKDLD KANYLSQALQ AGTVWINCYD VFGAQSPFGG YKMSGSGREL GEYGLQAYTE VKTVTVKVPQ KNS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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PTGDS

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