PSMG2

Alternative Names: Proteasome assembly chaperone 2, PAC-2, Hepatocellular carcinoma-susceptibility protein 3, Tumor necrosis factor superfamily member 5-induced protein 1, PSMG2, HCCA3, PAC2, TNFSF5IP1, CLAST3, MDS003, HsT1707, MGC15092.

Proteasome assembly chaperone 2 (PSMG2) helps assemble the 20S proteasome by forming a complex with PSMG1. This complex interacts with PSMA5 and PSMA7 subunits to facilitate the arrangement of alpha subunits into the alpha ring of the proteasome. Additionally, it prevents the dimerization of the alpha ring. PSMG2 is found in various tissues, with especially high levels in the lung, brain, and colon. It is moderately expressed in the muscle, stomach, spleen, and heart, and weakly expressed in the small intestine, pancreas, and liver. In hepatocellular carcinomas, PSMG2 is highly expressed, while surrounding liver tissue shows lower levels.

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  • Sku: PSB-pro-930-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Proteasome Assembly Chaperone 2, a member of the proteasome assembly chaperone family, is a protein involved in the assembly and maturation of the proteasome complex. With a molecular weight of approximately X kDa, this chaperone plays a significant role in ensuring the proper formation and functionality of the proteasome, a critical cellular machinery responsible for protein degradation. By assisting in the assembly process, Recombinant Human Proteasome Assembly Chaperone 2 contributes to the maintenance of cellular homeostasis and the regulation of various biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Activity Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 31.8 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation PSMG2 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 40% glycerol and 0.1M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMFVPCGE SAPDLAGFTL LMPAVSVGNV GQLAMDLIIS TLNMSKIGYF YTDCLVPMVG NNPYATTEGN STELSINAEV YSLPSRKLVA LQLRSIFIKY KSKPFCEKLL SWVKSSGCAR VIVLSSSHSY QRNDLQLRST PFRYLLTPSM QKSVQNKIKS LNWEEMEKSR CIPEIDDSEF CIRIPGGGIT KTLYDESCSK EIQMAVLLKF VSEGDNIPDA LGLVEYLNEW LQILKPLSDD PTVSASRWKI PSSWRLLFGS GLPPALF.

Storage Instruction

Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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PSMG2
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