PSMA4

Alternative Names: Proteasome subunit alpha type-4, Proteasome component C9, Proteasome subunit L, Macropain subunit C9, Multicatalytic endopeptidase complex subunit C9, PSMA4, HC9, PSC9, HsT17706.

PSMA4 is a member of the peptidase T1A family, specifically the 20S core alpha subunit. The proteasome is a highly organized proteinase complex with a ring-shaped 20S core structure. This core structure consists of four rings, each made up of 28 different subunits. Two of these rings are composed of seven alpha subunits, while the other two rings are composed of seven beta subunits. PSMA4 is found in high concentrations throughout eukaryotic cells and plays a role in cleaving peptides in a non-lysosomal pathway, relying on ATP and ubiquitin for its enzymatic activity.

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  • Sku: PSB-enz-222-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Proteasome Subunit Alpha Type 4 is a protein that plays a vital role in cellular protein degradation. Belonging to the proteasome subunit alpha family, this protein is responsible for maintaining cellular homeostasis by selectively breaking down damaged or misfolded proteins. With a molecular weight of approximately X kDa, it functions as a component of the 20S proteasome complex, which is involved in the degradation of ubiquitinated proteins. Understanding the functions and characteristics of Recombinant Human Proteasome Subunit Alpha Type 4 can provide valuable insights into cellular processes and potential therapeutic targets.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The PSMA4 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 1mM DTT and 0.1mM PMSF.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMSRRYD SRTTIFSPEG RLYQVEYAME AIGHAGTCLG ILANDGVLLA AERRNIHKLL DEVFFSEKIY KLNEDMACSV AGITSDANVL TNELRLIAQR YLLQYQEPIP CEQLVTALCD IKQAYTQFGG KRPFGVSLLY IGWDKHYGFQ LYQSDPSGNY GGWKATCIGN NSAAAVSMLK QDYKEGEMTL KSALALAIKV LNKTMDVSKL SAEKVEIATL TRENGKTVIR VLKQKEVEQL IKKHEEEEAK AEREKKEKEQ KEKDK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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PSMA4
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