PRTN3

Alternative Names: AGP7, Azurophil granule protein 7, P29, MBT, MBN, myeloblastin, PR-3, Neutrophil proteinase 4, ACPA, C-ANCA, Wegener granulomatosis autoantigen, Leukocyte proteinase 3, Serine proteinase neutrophil.

PRTN3 is a serine protease found in polymorphonuclear leukocytes. It has been shown to degrade several key proteins, including elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV in laboratory settings. When administered via tracheal insufflation in hamsters, PRTN3 has been linked to the development of emphysema.

Skip to product information
  • Sku: PSB-enz-075-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Human Proteinase-3 is a serine protease that belongs to the chymotrypsin family. It plays a role in the immune response by cleaving proteins involved in inflammation and tissue remodeling. Proteinase-3 has a molecular weight of approximately 29 kDa and is primarily found in neutrophil granules. Its enzymatic activity is regulated by specific inhibitors to prevent excessive proteolysis in the body.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Native
Purity 95 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation PRTN3is supplied in 20mM Sodium Phosphate pH-6.2, 300mM NaCl, and 0.02% Lubrol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

View full details

PRTN3

SUBHEADING

Recently viewed products