PPIL1

Alternative Names: Peptidyl-Prolyl Cis-Trans Isomerase-Like 1, PPIL-1, PPIL1, CYPL1, hCyPX, MGC678, PPIase, CGI-124

PPIL1 is a member of the cyclophilin family of PPIases which play a role in protein folding, immune suppression, and HIV-1 virion infection. It catalyzes the isomerization of proline imidic peptide bonds and is implicated in cancer cell proliferation by modulating stathmin phosphorylation. PPIL1 is a potential target for colon cancer therapy.

  •
  • Sku: PSB-enz-388-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Peptidylprolyl Isomerase (Cyclophilin)-Like 1, a member of the peptidylprolyl isomerase family, is a protein that plays a role in protein folding and trafficking within cells. With a molecular weight of approximately 18 kDa, this enzyme is involved in catalyzing the cis-trans isomerization of proline imidic peptide bonds in proteins, thereby influencing their conformation and function. Recombinant Human Peptidylprolyl Isomerase (Cyclophilin)-Like 1 is a valuable tool for studying protein folding mechanisms and may have potential applications in drug development and disease research.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin. Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation PPIL1 solution containing 20 mM Tris-HCl buffer (pH 8.0) and 20% glycerol

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MAAIPPDSWQ PPNVYLETSM GIIVLELYWK HAPKTCKNFA ELARRGYYNG TKFHRIIKDF MIQGGDPTGT GRGGASIYGK QFEDELHPDL KFTGAGILAM ANAGPDTNGS QFFVTLAPTQ WLDGKHTIFG RVCQGIGMVN RVGMVETNSQ DRPVDDVKII KAYPSGLEHH HHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
View full details

PPIL1
SUBHEADING

Recently viewed products