PINX1

Alternative Names: Protein 67-11-3, MGC8850, FLJ20565, LPTS, LPTL, TRF1-interacting protein 1, Liver-related putative tumor suppressor, PINX1, Pin2-interacting protein X1.

PINX1 is a widely expressed protein that localizes to nucleoli and telomere speckles. It contains a Telomerase Inhibiting Domain capable of binding MCRS1, TERT, and TERF1. Moreover, PINX1 serves as a potent telomerase inhibitor and potential tumor suppressor. The recruitment of PINX1 to the chromosome periphery by Nucleolin is crucial for accurate chromosome congression. Additionally, PINX1 plays a role in regulating the accumulation of TRF1 in nucleoli and its association with telomeres. Its involvement in the development of gastric cancer has been validated, and its expression levels serve as an indicator of gastric cancer development. Consequently, the constant expression of PINX1 is responsible for telomere maintenance through telomerase and plays a role in the tumorigenicity of cancer cells.

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  • Sku: PSB-pro-693-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human PIN2-Interacting Protein 1, also known as PIN1, is a protein that belongs to the peptidyl-prolyl cis-trans isomerase (PPIase) family. With a molecular weight of approximately 18 kDa, PIN1 plays a significant role in regulating protein conformational changes by catalyzing the cis-trans isomerization of proline residues. This protein is involved in various cellular processes, including cell cycle progression, DNA repair, and gene transcription. Its precise functions make it a subject of interest in numerous research fields, such as cancer biology and neurodegenerative diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The PINX1 protein contains 20mM Tris-HCl buffer pH-8, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSMLAERRRK QKWAVDPQNT AWSNDDSKFG QRMLEKMGWS KGKGLGAQEH GATDHIKVQV KNNHLGLGAT INNEDNWIAH QDDFNQLLAE LNTCHGQETT DSSDKKEKKS FSLEEKSKIS KNRVHYMKFT KGKDLSSRSK TDLDCIFGKR QSKKTPEGDA SPSTPEENET TTTSAFTIQE YFAKRMAALK NKPQVPVPGS DISETQVERK RGKKINKEAT GKDVESYLQP KAKRHTEGKP ERAEAQERVA KKKSAPAEEQ LRGPCWDQSS KASAQDAGDH VQPPEGRDFT LKPKKRRGKK KLQKPVEIAE DATLEETLVK KKKKKDSK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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PINX1

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