PIN4

Alternative Names: Glutaredoxin-1, Thioltransferase-1, TTase-1, Glrx, Glrx1, Grx, Grx1, Glutaredoxin-1, Thioltransferase-1, TTase-1, Glrx, Glrx1, Grx, Grx1.

GLRX1 is a versatile enzyme that exhibits glutathione-disulfide oxidoreductase activity alongside nadph and glutathione reductase. It is involved in reducing low molecular weight disulfides and proteins. Additionally, Glutaredoxin acts as a GSH-dependent hydrogen donor for ribonucleotide reductase and facilitates glutathione-disulfide oxidoreduction reactions alongside NADPH and glutathione reductase. GLRX1 also displays glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond plays a crucial role as an electron carrier in the enzyme ribonucleotide reductase's glutathione-dependent synthesis of deoxyribonucleotides. Furthermore, GLRX1 contributes to reducing cytosolic protein and non-protein disulfides in conjunction with glutathione reductase. This enzyme is essential for combatting reactive oxygen species (ROS) by directly reducing hydroperoxides and facilitating the detoxification of ROS-induced damage.

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  • Sku: PSB-enz-106-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Peptidyl-Prolyl Cis/Trans Isomerase NIMA-Interacting 4 is a member of the peptidyl-prolyl cis/trans isomerase family, which plays a role in protein folding and trafficking. This protein has a molecular weight of approximately 59 kDa. Its function involves catalyzing the cis-trans isomerization of proline imidic peptide bonds in oligopeptides, thereby influencing protein conformation and function. Recombinant Human Peptidyl-Prolyl Cis/Trans Isomerase NIMA-Interacting 4 is a crucial component in cellular processes involving protein folding and stability.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95.0 % by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 14.3 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation GLRX protein solution (0.5mg/ml) containing 20mM MES (pH5.0), 20% Glycerol and 0.1M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAQEFVN CKIQSGKVVV FIKPTCPYCR KTQEILSQLP FKQGLLEFVD ITATNNTSAI QDYLQQLTGA RTVPRVFIGK DCIGGCSDLI SMQQTGELMT RLKQIGALQL

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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PIN4
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