PGLYRP1, HEK

Alternative Names: Peptidoglycan recognition protein 1, peptidoglycan recognition protein short, PGLYRP, PGRP, PGRP-S, PGRPS, TAG7, TNFSF3L.

Peptidoglycan Recognition Protein 1 (PGLYRP1) is a member of the N-acetylmuramoyl-L-alanine amidase 2 family. It binds to bacterial peptidoglycan and impacts the synthesis of peptidoglycan. PGLYRP1 exhibits bactericidal effects on Gram-positive bacteria and bacteriostatic effects on Gram-negative bacteria. PGLYRP1 is involved in innate immunity and is found to be highly expressed in the bone marrow, with weaker expression in the kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen, and neutrophils.

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  • Sku: PSB-pro-2726-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Recombinant Human Peptidoglycan Recognition Protein 1, HEK is a protein that belongs to the family of peptidoglycan recognition proteins (PGRPs). PGRPs are a class of pattern recognition receptors involved in the innate immune response against bacterial infections. This particular variant of the protein is expressed in human embryonic kidney (HEK) cells. With a molecular weight of [insert weight], Recombinant Human Peptidoglycan Recognition Protein 1, HEK plays a significant role in recognizing and binding to peptidoglycan, a major component of bacterial cell walls, thereby initiating immune responses against bacterial pathogens.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System HEK 293
Purity 95.0 by SDS-PAGE
Activity
 Measured by its binding ability in a functional ELISA with Peptidoglycan. The ED50 range ≤ 30 ng/ml.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The PGLYRP1 solution (0.25mg/1ml) contains phosphate buffered saline (pH7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

DGSQETEDPA CCSPIVPRNE WKALASECAQ HLSLPLRYVV VSHTAGSSCN TPASCQQQAR NVQHYHMKTL GWCDVGYNFL IGEDGLVYEG RGWNFTGAHS GHLWNPMSIG ISFMGNYMDR VPTPQAIRAA QGLLACGVAQ GALRSNYVLK GHRDVQRTLS PGNQLYHLIQ NWPHYRSPHH HHHH

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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