PFN1

Alternative Names: Profilin-1, Profilin I, PFN1

Profilin1 (PFN1) is a widely distributed protein that binds to actin monomers and belongs to the profilin family. It has been shown to promote skin wound healing in both in-vitro and in-vivo settings, possibly through the involvement of purinergic receptors. Additionally, PFN1 is involved in the migration of endothelial cells and the development of blood vessels. It is believed that PFN1 regulates actin polymerization in response to signals from the surroundings. PFN1 directly binds to actin and impacts the assembly of the cytoskeleton. Moreover, PFN1 plays a crucial role in regulating the adhesion between epithelial cells. At high concentrations, profilin prevents actin polymerization, while at low concentrations, it enhances it. Deletion of the PFN1 gene is associated with Miller-Dieker syndrome.

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  • Sku: PSB-pro-528-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Profilin-1 is a protein that belongs to the profilin family. With a molecular weight of approximately 15 kDa, it plays a significant role in regulating actin dynamics and cytoskeletal organization. This protein acts as a crucial modulator of cell motility, intracellular signaling, and membrane trafficking processes. Recombinant Human Profilin-1 is widely utilized in various research applications, including studies on cell biology, cancer metastasis, and immune response mechanisms. Its precise and controlled expression allows for in-depth investigations into the intricate mechanisms underlying cellular processes, making it a valuable tool for scientific exploration.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The PFN1 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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PFN1
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