PDGFAB

Alternative Names: PDGF-AB, GDGF, ODGF, Glioma-derived growth factor, Osteosarcoma-derived Growth Factor

PDGF is a group of dimeric isoforms that function as autocrine and paracrine growth factors and are produced by various cell types other than platelets. They have a strong mitogenic effect on mesenchymally-derived cells. Abnormal expression of PDGF is linked to certain cancers, fibroproliferative disorders, and atherosclerosis. PDGF also plays a role in wound healing and neural regeneration. The PDGF family consists of four members: PDGF A, PDGF B, PDGF C, and PDGF D. PDGF-A has two forms - a soluble short form and a long form that is attached to the extracellular matrix.

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  • Sku: PSB-cyt-342-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Platelet Derived Growth Factor-AB (rhPDGF-AB) is a protein that belongs to the PDGF family. With a molecular weight of approximately 28 kDa, rhPDGF-AB plays a significant role in various biological processes, including cell proliferation, differentiation, and tissue repair. This growth factor is commonly used in research and clinical settings to study and promote wound healing, bone regeneration, and tissue engineering. Its precise and controlled administration has shown promising results in accelerating the healing process and enhancing tissue regeneration.

Current Lead Time

7-14 Days

Product Specifications

Species
human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
The ED50 as determined by the dose-dependent proliferation of mouse 3T3 indicator cells, is 1.4-2.1 ng/ml. This corresponds to a specific activity of 7.1x 105 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
14.3 kDa
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized from 10mM AcOH (Acetic Acid).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Alpha chain: MSIEEAVPAV CKTRTVIYEI PRSQVDPTSA NFLIWPPCVE VKRCTGCCNT SSVKCQPSRV HHRSVKVAKV EYVRKKPKLK EVQVRLEEHL ECACATTSLN PDYREEDTGR PRESGKKRKR KRLKPT.Beta chain: SLGSLTIAEP AMIAECKTRT EVFEISRRLI DRTNANFLVW PPCVEVQRCS GCCNNRNVQC RPTQVQLRPV QVRKIGIVRK KPIFKKATVT LGDHLACKCE TVAAARPVT.

Storage Instruction

Lyophilized Platelet-derived Growth Factor AB although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution PDGF-AB should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Platelet-derived Growth Factor-AB in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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PDGFAB

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