PDE6D

Alternative Names: Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, Phosphodiesterase 6D cGMP-Specific Rod Delta, GMP-PDE delta, Protein p17, PDE6D, PDED.

Human PDE6D is a component of rod-specific cGMP phosphodiesterase, PDE6, consisting of two catalytic chains (alpha and beta) and an inhibitory chain (gamma). PDE6D interacts with RPGR, ARL2, and ARL3 but its specific function remains unknown as it does not alter the catalytic properties of PDEαβ. PDE6D is found exclusively in the retina.

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  • Sku: PSB-enz-483-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Phosphodiesterase 6D cGMP-Specific Rod Delta is a member of the phosphodiesterase enzyme family, specifically targeting cGMP in rod cells. This enzyme plays a critical role in the regulation of cGMP levels, which are essential for proper vision. Recombinant Human Phosphodiesterase 6D cGMP-Specific Rod Delta has a molecular weight of approximately 90 kDa, making it a key player in the visual transduction pathway.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
18.4 kDa
Structure Heterodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The PDE6D protein solution contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 1mM DTT and 100mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSAKDERARE ILRGFKLNWM NLRDAETGKI LWQGTEDLSV PGVEHEARVP KKILKCKAVS RELNFSSTEQ MEKFRLEQKV YFKGQCLEEW FFEFGFVIPN STNTWQSLIE AAPESQMMPA SVLTGNVIIE TKFFDDDLLV STSRVRLFYV GSHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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PDE6D

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