PAPP-A

Alternative Names: Pappalysin-1, Pregnancy-associated plasma protein A, PAPP-A, IGF-dependent IGFBP-4 protease, IGFBP-4ase, PAPPA, PAPA, DIPLA1, PAPPA1, ASBABP2.

PAPPA is a zinc-binding protein that functions as a metalloprotease, cleaving IGFBP-4 and IGFBP-5 to release bound IGF. It plays a role in regulating IGF bioactivity in various biological systems, such as the ovary and cardiovascular system. Elevated levels of PAPP A have been observed in patients with unstable angina and myocardial infarction. It is involved in processes like wound healing and bone remodeling. During pregnancy, PAPP-A is produced in high concentrations and released into the maternal circulation. It is found in placental cells and in various tissues like the kidney, myometrium, and breast. Low PAPP A levels are associated with chromosomal abnormalities in fetuses, as well as conditions like pre-eclampsia and stillbirth. PAPPA levels could potentially serve as a specific marker for heart disease. Its proteolytic activity can be inhibited by targeting substrate exosite binding.

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  • Sku: PSB-enz-441-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Pregnancy-Associated Plasma Protein-1 (PAPP-A) is a protein belonging to the metalloproteinase family. It plays a role in regulating insulin-like growth factor signaling and is involved in various physiological processes such as cell growth and differentiation. PAPP-A has a molecular weight of approximately 200 kDa and is commonly used in research studies to investigate its functions and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 25.75 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation PAPP-A protein is supplied in 20mM Tris Hcl PH 8.0, 4M Urea and 50% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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PAPP-A
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