oLeptin qA

Alternative Names: Not Available

The Recombinant Ovine Leptin Quadruple Antagonist is a synthetic protein that belongs to the family of leptin antagonists. With a molecular weight of [insert weight], this antagonist is designed to inhibit the activity of leptin, a hormone primarily involved in regulating energy balance and appetite. By targeting and blocking the effects of leptin, this recombinant protein offers potential therapeutic applications in the field of obesity and related metabolic disorders. Its precise mechanism of action and potential benefits make it a subject of scientific interest and research.

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  • Sku: PSB-cyt-357-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

The Recombinant Ovine Leptin Quadruple Antagonist is a synthetic protein that belongs to the family of leptin antagonists. With a molecular weight of [insert weight], this antagonist is designed to inhibit the activity of leptin, a hormone primarily involved in regulating energy balance and appetite. By targeting and blocking the effects of leptin, this recombinant protein offers potential therapeutic applications in the field of obesity and related metabolic disorders. Its precise mechanism of action and potential benefits make it a subject of scientific interest and research.

Current Lead Time

7-14 Days

Product Specifications

Species
Sheep
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
ProSpec’s leptin qA is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of ovine leptin receptor. It also inhibits various leptin effects in several in vitro bioassays. ProSpec’s leptin qA is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of ovine leptin receptor. It also inhibits various leptin effects in several in vitro bioassays.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045mM NaHCO3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Val-Pro-Ile-Arg.

Storage Instruction

Lyophilized Leptin-Antagonist Quadruple Mutant Ovine Recombinant although stable at room temperature for several weeks, should be stored desiccated below -18°C. Upon reconstitution at > 0.1 LEP-qA mutant mg/ml and up to 2mg/ml and filter sterilization Leptin mutant can be stored at 4°C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. At lower concentration addition of a carrier protein (0.1% HSA or BSA) is suggested. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Leptin-Antagonist Quadruple Mutant Ovine Recombinant in sterile 0.4% NaHCO3 adjusted to pH 8-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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oLeptin qA

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