oGH Antagonist

Alternative Names: GH, GH1, GHN, GH-N, hGH-N, Pituitary growth hormone, Growth hormone 1, Somatotropin.

GH is a hormone in the somatotropin/prolactin family that plays a crucial role in growth regulation. It is located on chromosome 17 along with four other related genes. These genes are arranged in the same direction, indicating they evolved through gene duplications. The five genes have a high level of similarity in their genetic sequences. Alternative splicing of these genes produces different versions of growth hormones, increasing diversity and potential specialization. Unlike the other four genes in the growth hormone locus, this particular member is only expressed in the pituitary gland, not in placental tissue. Mutations or deletions of this gene result in growth hormone deficiency and short stature.

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  • Sku: PSB-cyt-215-20µg
  • Vendor: ProSpec-Tany
$150.00 USD
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Title

Product Details

Product Description

The Recombinant Ovine Growth Hormone Antagonist is a synthetic protein designed to inhibit the effects of growth hormone in ovine species. Belonging to the family of growth hormone antagonists, this bioengineered protein is specifically developed for its ability to bind to growth hormone receptors, blocking their activation and subsequent downstream signaling pathways. With a molecular weight of approximately X kilodaltons, this recombinant antagonist offers a targeted approach to regulate growth hormone activity in ovine species, facilitating scientific research and potential applications in animal husbandry.

Current Lead Time

7-14 Days

Product Specifications

Species
Sheep
Expression System E. coli
Purity 98.0 % by SDS-PAGE
Activity
GH G119R acts as antagonist using an in vitro bioassay in PDF-P1 3B9 cells stably transfected with rabbit GH receptors. It is capable of forming a 1:1 complex with the recombinant ovine growth hormone receptor extracellular domain (ECD) and binds to this ECD with affinity similar the the wild type oGH. GH G119R acts as antagonist using an in vitro bioassay in PDF-P1 3B9 cells stably transfected with rabbit GH receptors. It is capable of forming a 1:1 complex with the recombinant ovine growth hormone receptor extracellular domain (ECD) and binds to this ECD with affinity similar the the wild type oGH.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The protein was lyophilized from a concentrated (1mg/ml) solution with 0.0045M NaHCO3, pH 9.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Thr-Phe-Pro-Ala.

Storage Instruction

Lyophilized GH G119R although stable at room temperature for at least two weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization GH can be stored at 4°C, pH 9 for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized GH G119R in 0.4% NaHCO3 or water adjusted to pH 9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions, preferably in a presence of a carrier protein such as BSA or similar.

References

Not Available

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oGH Antagonist

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