NUDT5

Alternative Names: ADP-sugar pyrophosphatase, EC=3.6.1.-, EC=3.6.1.13, HSPC115, hYSAH1, Nucleoside diphosphate-linked moiety X motif 5, Nudix motif 5, YSA1, YSA1H

NUDT5, a member of the nudix hydrolase family, enzymatically breaks down toxic nucleotide derivatives within cells. Specifically, NUDT5 targets ADP-ribose, ADP-mannose, and other nucleotide sugars in the presence of magnesium. Its main function is to maintain appropriate levels of signaling nucleotides by eliminating harmful nucleotide metabolites. NUDT5 is highly expressed in the liver, predominantly as a homodimer.

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  • Sku: PSB-enz-547-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Nudix Type Motif 5 (NUDT5) is a member of the Nudix hydrolase enzyme family, which is involved in the hydrolysis of nucleoside diphosphate linked to another moiety, such as a metal ion or sugar. NUDT5 is responsible for the hydrolysis of ADP-ribose, a key molecule involved in various cellular processes. This enzyme has a molecular weight of approximately 17.7 kDa and plays a role in maintaining cellular homeostasis through its enzymatic activity.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation NUDT5 Human 1mg/ml solution containing 20mM Tris-HCl pH-8, 1mM DTT, 0.1M NaCl & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MESQEPTESS QNGKQYIISE ELISEGKWVK LEKTTYMDPT GKTRTWESVK RTTRKEQTAD GVAVIPVLQR TLHYECIVLV KQFRPPMGGY CIEFPAGLID DGETPEAAAL RELEEETGYK GDIAECSPAV CMDPGLSNCT IHIVTVTING DDAENARPKP KPGDGEFVEV ISLPKNDLLQ RLDALVAEEH LTVDARVYSY ALALKHANAK PFEVPFLKF.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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NUDT5
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