NRG1 B1

Alternative Names: Neuregulin-1, NRG1-B1, Heregulin-b1, NRG1 B1.

Neuregulin/Heregulin is a group of polypeptide growth factors derived from different genes (NRG1, NRG2, NRG3 and NRG4). The NRG1 gene produces over 14 proteins, some of which are soluble growth factors. HRG1-b1, one of these proteins, has an Ig domain and an EGF-like domain that bind to receptor tyrosine kinases erb3 and erb4. This binding promotes the formation of heterodimers with erb2, activating its kinase activity and causing tyrosine phosphorylation. The biological effects of HRG1-b1 are not fully understood, but it has been found to increase the motility and invasiveness of breast cancer cells, potentially by up-regulating the expression and function of the autocrine motility-promoting factor (AMF).

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  • Sku: PSB-cyt-733-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Neuregulin-1/Heregulin-b1 is a protein that belongs to the epidermal growth factor (EGF) family. With a weight of approximately 8.0 kDa, this protein plays a significant role in cellular communication and development. It acts as a ligand for various receptor tyrosine kinases, particularly ErbB3 and ErbB4, and is involved in the regulation of cell proliferation, differentiation, and survival. Recombinant Human Neuregulin-1/Heregulin-b1 is widely studied in the field of molecular biology and holds potential for therapeutic applications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is less than 0.5ng/ml, corresponding to a specific activity of >2.0×106 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered solution in 1×PBS, pH 7.4 and 5% trehalose.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE.

Storage Instruction

Lyophilized NRG1-B1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NRG1-B1 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized NRG1-B1 in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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NRG1 B1
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