NRG1 A

Alternative Names: Heregulin Alpha, NRG1-A, NRG1 A, Neuregulin-1.

Neuregulin/Heregulin is a group of related polypeptide growth factors derived from different genes (NRG1, NRG2, NRG3 and NRG4). The NRG1 gene produces over 14 proteins, some of which are soluble growth factors. These proteins, such as heregulins (HRGs), glial growth factors (GGFs) and sensory and motor neuron-derived factor (SMDF), contain the Ig and EGF-like domain. They can bind to ErbB3 and ErbB4 receptor tyrosin kinases, promoting tyrosine phosphorylation. This activation leads to the growth and differentiation of various cell types including epithelial, neuronal, glial, and others.

  •
  • Sku: PSB-cyt-736-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Neuregulin-1/Heregulin Alpha (EGF Domain) is a protein belonging to the neuregulin family, which plays a vital role in various cellular processes. This protein has a molecular weight of approximately X kDa and is involved in cell growth, differentiation, and development. It acts as a ligand for the ErbB family of receptors, particularly ErbB3 and ErbB4, thereby activating downstream signaling pathways. Understanding the functions and mechanisms of Recombinant Human Neuregulin-1/Heregulin Alpha (EGF Domain) is of great importance in elucidating its potential therapeutic applications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is less than 40 ng/ml, corresponding to a specific activity of > 2.5×104 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered solution in 20mM PB, pH 6.0 and 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCQPGF TGARCTENVP MKVQNQEKAE ELYQK.

Storage Instruction

Lyophilized NRG1-A although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution NRG1-A should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized NRG1-A in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
View full details

NRG1 A
SUBHEADING

Recently viewed products