NQO1

Alternative Names: NAD(P)H dehydrogenase (quinone) 1, NAD(P)H:quinone oxidoreductase 1, Quinone reductase 1, QR1, DT-diaphorase, DTD, Azoreductase, Phylloquinone reductase, Menadione reductase, NQO1, DIA4, NMOR1, DHQU, NMORI.

NQO1, a member of the NAD(P)H dehydrogenase (quinone) family, functions as a cytoplasmic 2-electron reductase crucial for cellular antioxidant defense. It plays a key role in preventing the formation of reactive oxygen species by detoxifying quinines. Additionally, NQO1 is involved in conjugation reactions of hydroquinones in detoxification pathways and biosynthetic processes like the gamma-carboxylation of glutamate residues in prothrombin synthesis. Changes in NQO1 expression have been observed in tumors and Alzheimer's disease. Mutations in the NQO1 gene are associated with conditions such as tardive dyskinesia, increased risk of hematotoxicity from benzene exposure, and susceptibility to various cancers.

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  • Sku: PSB-enz-448-2µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human NAD(P)H Dehydrogenase Quinone 1 is a member of the NADH dehydrogenase (ubiquinone) family, responsible for catalyzing the oxidation of NADH and reduction of ubiquinone in the mitochondrial respiratory chain. This enzyme plays a crucial role in electron transport and energy production within the cell. With a molecular weight of approximately 75 kDa, Recombinant Human NAD(P)H Dehydrogenase Quinone 1 is a key player in maintaining cellular redox balance and mitochondrial function.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The NQO1 solution contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MVGRRALIVL AHSERTSFNY AMKEAAAAAL KKKGWEVVES DLYAMNFNPI ISRKDITGKL KDPANFQYPA ESVLAYKEGH LSPDIVAEQK KLEAADLVIF QFPLQWFGVP AILKGWFERV FIGEFAYTYA AMYDKGPFRS KKAVLSITTG GSGSMYSLQG IHGDMNVILW PIQSGILHFC GFQVLEPQLT YSIGHTPADA RIQILEGWKK RLENIWDETP LYFAPSSLFD LNFQAGFLMK KEVQDEEKNK KFGLSVGHHL GKSIPTDNQI KARK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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NQO1
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