NGB His

Alternative Names: "NGB. "

Neuroglobin is a protein consisting of 151 amino acid residues. It is primarily found in the brain and retina of vertebrates and belongs to the globin superfamily. It plays a crucial role in providing oxygen to the brain, which helps neurons survive during low oxygen levels, potentially minimizing brain damage. Additionally, neuroglobin appears to act as a sensor for oxidative stress signals in the brain. Studies have shown that neuroglobin expression increases in response to hypoxia in neuronal cells cultured in the lab, as well as in cases of ischemic stroke. Inhibiting neuroglobin expression with antisense oligodeoxynucleotide reduces neuronal survival after hypoxia, whereas increasing expression of neuroglobin enhances neuronal survival.

Skip to product information
  • Sku: PSB-cyt-1030-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human Neuroglobin His Tag is a protein that belongs to the globin family. With a weight of approximately 19 kDa, this protein plays a significant role in various physiological processes. It exhibits a high affinity for oxygen and is predominantly expressed in the brain, where it contributes to neuroprotection and neuronal survival. The inclusion of a histidine (His) tag allows for easy purification and detection of the protein, making it a valuable tool for research in neuroscience and related fields.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation NGB is Filtered (0.4μm) and lyophilized from 0.5mg/ml in phosphate buffered saline.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHAS MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Neuroglobin is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

References

Not Available

View full details

NGB His

SUBHEADING

Recently viewed products