NEFL

Alternative Names: Neurofilament light polypeptide, NF-L, NEFL, NF68, NFL, 68 kDa neurofilament protein, Neurofilament light polypeptide, NF-L, NEFL, NF68, NFL, 68 kDa neurofilament protein.

NEFL, also known as the neurofilament light polypeptide, is a protein produced by the NEFL gene. It is associated with Charcot-Marie-Tooth disease. Detection of NEFL's light subunit in plasma and cerebrospinal fluid can indicate axonal damage in neurological conditions. Therefore, NEFL can serve as a marker for Huntington's disease, Amyotrophic Lateral Sclerosis, and multiple sclerosis.

Skip to product information
  • Sku: PSB-pro-2584-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human Neurofilament Light (NF-L) is a protein belonging to the neurofilament family, which plays a critical role in maintaining the structural integrity of neurons. With a molecular weight of approximately 68 kDa, NF-L is primarily expressed in neurons of the central and peripheral nervous systems. As a key component of the neuronal cytoskeleton, NF-L provides mechanical support and facilitates axonal transport. Its precise quantification and analysis have emerged as valuable tools in neurodegenerative diseases, such as Alzheimer's and Parkinson's, aiding in the assessment of neuronal damage and disease progression.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90.0 % by SDS-PAGE
Activity
Activity Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation NEFL filtered (0.4 µm) and lyophilized from 0.5mg/ml solution in 15mM Tris and 85mM Glycine, pH 8.5. NEFL filtered (0.4 µm) and lyophilized from 0.5mg/ml solution in 15mM Tris and 85mM Glycine, pH 8.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MKHHHHHHAS SFSYEPYYST SYKRRYVETP RVHISSVRSG YSTARSAYSS YSAPVSSSLS VRRSYSSSSG SLMPSLENLD LSQVAAISND LKSIRTQEKA QLQDLNDRFA SFIERVHELE QQNKVLEAEL LVLRQKHSEP SRFRALYEQE IRDLRLAAED ATNEKQALQG EREGLEETLR NLQARYEEEV LSREDAEGRL MEARKGADEA ALARAELEKR IDSLMDEISF LKKVHEEEIA ELQAQIQYAQ ISVEMDVTKP DLSAALKDIR AQYEKLAAKN MQNAEEWFKS RFTVLTESAA KNTDAVRAAK DEVSESRRLL KAKTLEIEAC RGMNEALEKQ LQELEDKQNA DISAMQDTIN KLENELRTTK SEMARYLKEY QDLLNVKMAL DIEIAAYRKL LEGEETRLSF TSVGSITSGY SQSSQVFGRS AYGGLQTSSY LMSTRSFPSY YTSHVQEEQI EVEETIEAAK AEEAKDEPPS EGEAEEEEKD KEEAEEEEAA EEEEAAKEES EEAKEEEEGG EGEEGEETKE AEEEEKKVEG AGEEQAAKKK D.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized C-Peptide in sterile 18MΩ-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

View full details

NEFL

SUBHEADING

Recently viewed products