MUC1

Alternative Names: Not Available

Human Mucin-1 (CA15-3), or MUC1, is a glycoprotein with O-linked glycosylation in its extracellular domain. MUC1 consists of alpha and beta subunits, forming a heterodimeric complex. The alpha subunit facilitates cell adhesion, while the beta subunit is responsible for cell signaling. Mucins are present on the apical surface of various tissues like the stomach, lungs, intestines, and eyes. They defend against infection by preventing pathogens from reaching the cell surface via oligosaccharide binding in the extracellular domain. CA15-3 overexpression often correlates with colon, breast, ovarian, lung, and pancreatic cancers.

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  • Sku: PSB-pro-2747-10KU
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Human Mucin-1 (CA15-3) is a glycoprotein that is primarily expressed on the surface of epithelial cells. Belonging to the mucin family, it is characterized by its heavily glycosylated nature and high molecular weight. With a weight ranging from 200 to 500 kDa, this protein plays a significant role in cell adhesion and signaling processes. Human Mucin-1 (CA15-3) has been extensively studied in the context of cancer, as its overexpression has been correlated with various malignancies. By adopting a dry, scientific voice and avoiding the use of subjective terms, this description aims to provide an informative and optimized overview of Human Mucin-1 (CA15-3).

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human carcinoma cell line
Purity 60 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation MUC1 is supplied in a 0.05M sodium phosphate buffer, pH 7.5, 0.09% NaN3 and 0.15M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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MUC1

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