mTARC

Alternative Names: Thymus and activation-regulated chemokine, CC chemokine TARC, C-C motif chemokine 17, Small-inducible cytokine A17, ABCD-2, CCL17, CCL-17, SCYA17, TARC, A-152E5.3, MGC138271, MGC138273.

TARC cDNA encodes a 94 amino acid protein, with a 23 amino acid signal peptide that is removed to create a 71 amino acid mature secreted protein. TARC shares sequence identity with various chemokines and is expressed in multiple tissues, primarily in the thymus. It is also transiently expressed in stimulated peripheral blood mononuclear cells. TARC is chemotactic for T cell lines but not monocytes or neutrophils. CCL-17, a ligand for the receptor CCR4, is part of the CC cytokine gene cluster on chromosome 16. It specifically attracts T lymphocytes, binding to CCR4 and CCR8. CCL17 is involved in T cell development, trafficking, and activation.

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  • Sku: PSB-chm-270-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Mouse Thymus and Activation Regulated Chemokine (CCL17) is a chemokine protein belonging to the CC chemokine family. It plays a role in immune response regulation by attracting immune cells to sites of inflammation. This chemokine has a molecular weight of approximately 8.5 kDa. Recombinant Mouse CCL17 is commonly used in research studies to investigate its role in various inflammatory diseases and immune disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 The ED50 as determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR4 is typically 2-10 ng/ml. The ED50 as determined by its ability to chemoattract BaF3 mouse pro-B cells transfected with human CCR4 is typically 2-10 ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ARATNVGREC CLDYFKGAIP IRKLVSWYKT SVECSRDAIV FLTVQGKLIC ADPKDKHVKK AIRLVKNPRP.

Storage Instruction

Lyophilized TARC although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TARC should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).ase prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized TARC in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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mTARC
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