mSDF1a

Alternative Names: CXCL12, chemokine (C-X-C motif) ligand 12, hIRH, Pre-B cell growth-stimulating factor, PBSF, SDF-1, SDF1, SDF1A, SDF-1a, SCYB12, TPAR1, TLSF, TLSF-a, Thymic lymphoma cell-stimulating factor, 12-O-tetradecanoylphorbol 13-acetate repressed protein 1

SDF-1, also known as CXCL12, is a small cytokine belonging to the chemokine family. It is produced in two forms, SDF-1α/CXCL12a and SDF-1β/CXCL12b, through alternate splicing of the same gene. CXCL12 is a CXC chemokine with four conserved cysteines, two of which form disulfide bonds. It plays a key role in directing the migration of hematopoietic cells during embryonic development. Knock-out mice for the CXCL12 gene did not survive long after birth. CXCL12 is also involved in altering the electrophysiology of neurons. It is expressed in various tissues in mice, such as the brain, thymus, and spleen. The receptor for CXCL12 is CXCR4, previously known as fusin, although recent studies suggest CXCR7 may also bind to CXCL12. The gene for CXCL12 is located on human chromosome 10 and shows high sequence identity in both humans and mice.

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  • Sku: PSB-chm-324-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Mouse Stromal Cell-Derived Factor-1 alpha (CXCL12) is a chemokine protein belonging to the CXC subfamily. It plays a critical role in immune responses and hematopoiesis by regulating the migration of leukocytes. This protein has a molecular weight of approximately 8.4 kDa and is involved in various physiological processes, including inflammation and tissue repair. Recombinant Mouse CXCL12 is commonly used in research studies to investigate its functions and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 95 % by SDS-PAGE
Activity
 The specific activity as determined by its ability to chemoattract human peripheral blood monocytes at 50-100 ng/ml corresponding to a Specific Activity of 10,000-20,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was Lyophilized from a sterile filtered aqueous solution containing 0.1% Trifluoroacetic Acid (TFA).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Lys-Pro-Val-Ser-Leu.

Storage Instruction

Lyophilized SDF-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL12 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Stromal Cell-Derived Factor-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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mSDF1a
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