ms100b

Alternative Names: Not Available

S100b is a type of protein that belongs to the S100 family. This family consists of calcium-binding proteins called EF-hand proteins, which are usually found as dimers made up of 20 individual S100 monomers. S100B homodimers are present in cells of the central nervous system, glial cells, and certain peripheral cells like Schwann cells, melanocytes, adipocytes, and chondrocytes. These proteins are located either in the cytoplasm or the nucleus of various cells and are involved in regulating cellular processes such as cell cycle progression and differentiation. S100b is one of the 13 members of the S100 gene family, which are found together on chromosome 1q21. However, S100b itself is located at 21q22.3. Measurement of S100B levels in the blood is used to assess brain injury severity and malignant melanoma progression. S100b proteins have various functions, including promoting neurite extension, stimulating melanoma cell growth, modulating calcium flow, inhibiting a specific type of protein phosphorylation, promoting astrocyte and axonal growth, and disrupting microtubule assembly. Changes in the structure and expression of the S100b gene are associated with neurological disorders, cancerous conditions, and other diseases like Alzheimer's, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

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  • Sku: PSB-pro-2370-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Mouse S100 Calcium Binding Protein B, also known as S100B, is a member of the S100 protein family. This protein plays a significant role in calcium-dependent signaling pathways and is involved in various cellular processes. With a molecular weight of approximately 10.5 kDa, S100B is primarily expressed in astrocytes and acts as a biomarker for brain injury and neurodegenerative disorders. Its binding affinity to calcium ions enables it to modulate the activity of target proteins, thereby influencing multiple physiological functions. Understanding the properties and functions of Recombinant Mouse S100 Calcium Binding Protein B is crucial for investigating its implications in various diseases and developing potential therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 10.7 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The s100b protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSELEKAMVA LIDVFHQYSG REGDKHKLKK SELKELINNE LSHFLEEIKE QEVVDKVMET LDEDGDGECD FQEFMAFVAM VTTACHEFFE HE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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ms100b
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