mPRDX1

Alternative Names: Not Available

PRDX1 is a member of the peroxiredoxin family, an group of antioxidant enzymes that have the ability to reduce hydrogen peroxide and alkyl hydroperoxides. It plays a significant role in protecting red blood cells from harmful reactive oxygen species and in preventing tumor development. In addition, PRDX1 contributes to the antiviral activity of CD8(+) T-cells and has a promoting effect on cell proliferation, which is related to cancer development and progression. Functionally, PRDX1 is involved in the regulation of cellular redox state by reducing peroxides through the thioredoxin system, independent of the glutaredoxin pathway. It also plays a role in the elimination of peroxides produced during cellular metabolism. Moreover, PRDX1 is involved in the regulation of intracellular concentrations of h(2)o(2) through its participation in the signaling pathways of growth factors and TNF-alpha.

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  • Sku: PSB-enz-951-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Mouse Peroxiredoxin-1 is a protein that belongs to the peroxiredoxin family, which plays a significant role in antioxidant defense mechanisms. With a molecular weight of approximately 22 kDa, this protein is involved in the reduction of hydrogen peroxide and organic hydroperoxides, thereby protecting cells from oxidative stress. Recombinant Mouse Peroxiredoxin-1 is commonly used in scientific research to study its enzymatic activity and explore its potential therapeutic applications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System Sf9 - Baculovirus cells
Purity 90% by SDS-PAGE
Activity
 Specific activity is >2,500 pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25°C for minute.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation PRDX1 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSSGNAKIGY PAPNFKATAV MPDGQFKDIS LSEYKGKYVV FFFYPLDFTF VCPTEIIAFS DRADEFKKLN CQVIGASVDS HFCHLAWINT PKKQGGLGPM NIPLISDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITINDLPVG RSVDEIIRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVNK SKEYFSKQKL EHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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mPRDX1
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