mPEBP1

Alternative Names: HCNPpp, Phosphatidylethanolamine-binding protein 1, PEBP-1

PEBP1, a member of the phosphatidylethanolamine-binding protein family, acts as a serine protease inhibitor and inhibits thrombin and neuropsin. It plays a crucial role in various protein kinase signaling cascades. PKC phosphorylates PEBP1, leading to the release of Raf-1 and the activation of MEK and ERK. PEBP1 is expressed in multiple tissues and is involved in regulating processes such as membrane biosynthesis, spermatogenesis, neural development, and suppression of metastasis. PEBP1 has the ability to bind to ATP, opioids, and phosphatidylethanolamine, although it has a lower affinity for phosphatidylinositol and phosphatidylcholine. It may also play a role in the functioning of presynaptic cholinergic neurons in the central nervous system. PEBP1 increases the production of choline acetyltransferase but not acetylcholinesterase. Additionally, it can potentially sequester toxic compounds, including locostatin, which may be harmful to cells. Loss of PEBP1 expression can serve as a prognostic marker in gastrointestinal stromal tumors. It is also found to be differentially expressed in the Wernicke's Area of schizophrenia patients. Moreover, PEBP1 acts as an invasion suppressor protein in nasopharyngeal carcinoma.

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  • Sku: PSB-pro-2230-5µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Mouse Phosphatidylethanolamine Binding Protein 1 (PEBP1) is a member of the phosphatidylethanolamine binding protein family. With a molecular weight of approximately X kDa, PEBP1 plays a significant role in various cellular processes. This protein is involved in regulating signal transduction pathways, lipid metabolism, and cell proliferation. By binding to phospholipids, PEBP1 modulates the activity of key enzymes and acts as a molecular chaperone. Understanding the functions and mechanisms of PEBP1 can provide valuable insights into the intricate workings of cellular systems.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 23.2 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation PEBP1 protein solution (1mg/ml) containing Phosphate Buffered Saline (pH7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAADISQ WAGPLCLQEV DEPPQHALRV DYAGVTVDEL GKVLTPTQVM NRPSSISWDG LDPGKLYTLV LTDPDAPSRK DPKFREWHHF LVVNMKGNDI SSGTVLSDYV GSGPPSGTGL HRYVWLVYEQ EQPLSCDEPI LSNKSGDNRG KFKVETFRKK YNLGAPVAGT CYQAEWDDYV PKLYEQLSGK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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mPEBP1
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