MMP9

Alternative Names: Matrix metalloproteinase-9, MMP-9, 92 kDa gelatinase, Gelatinase B, GELB, MMP9, CLG4B.

Matrix metalloproteinases, or MMPs, are a group of enzymes that break down extracellular matrix proteins. Specifically, MMP9 is secreted as a 92kDa zymogen and, once cleaved, becomes an active enzyme with a molecular weight of around 82kDa. It is made up of various domains including a gelatin-binding domain, a catalytic domain, a proline-rich domain, and a hemopexin-like domain. MMP9 is produced by different cell types such as monocytes, macrophages, and fibroblasts, and is involved in processes like inflammation, wound healing, and tumor growth. MMP9 can break down type IV and V collagens, and is implicated in conditions like intervertebral disc disease.

  •
  • Sku: PSB-enz-438-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Recombinant Human Matrix Metalloproteinase-9 (MMP-9) is a member of the matrix metalloproteinase family, which plays a key role in the breakdown of extracellular matrix proteins. MMP-9 is a zinc-dependent endopeptidase that is involved in tissue remodeling and wound healing processes. With a molecular weight of approximately 92 kDa, MMP-9 is known for its ability to degrade type IV and V collagen, as well as other components of the extracellular matrix. Its dysregulation has been implicated in various pathological conditions, including cancer metastasis and inflammatory diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation MMP-9 protein is supplied in 20mM Tris-HCl pH 8.0 and 50% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

4.5kDa His Tag-DLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTRDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGP.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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MMP9
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