MMP8

Alternative Names: EC 3.4.24.34, Matrix metalloproteinase-8, MMP-8, PMNL-CL, HNC, CLG1.

Recombinant human neutrophil MMP-8 is a enzyme that degrades collagen type I in the skin. This protein is mainly expressed by neutrophils, where it is synthesized and stored in specific granules. MMP-8 activity is regulated by factors like IgG or complement components, which trigger its release through degranulation. When activated, MMP-8 is involved in the turnover of connective tissue during inflammatory processes.

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  • Sku: PSB-enz-301-1U
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Matrix Metalloproteinase-8 (MMP-8) is a member of the matrix metalloproteinase family, which plays a key role in the breakdown of extracellular matrix proteins. MMP-8 is involved in tissue remodeling and wound healing processes. This enzyme has a molecular weight of approximately 57 kDa and is commonly used in research and pharmaceutical applications for its ability to degrade collagen and other components of the extracellular matrix. Its enzymatic activity makes it a valuable tool for studying the role of matrix metalloproteinases in various biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 100 units/ml after activation with APMA by solution assay method. One unit of collagenolytic activity is defined as the cleavage of 1µg of collagen per minute by the solution method.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The MMP-8 protein solution (100 units/ml) in 0.05M Tris-HCl buffer, pH 7.6, 0.2M NaCl, 5mM CaCl2, 0.0025% NaN3 and 0.1% BSA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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MMP8
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