MMP7, Active

Alternative Names: Matrilysin, EC 3.4.24.23, Pump-1 protease, Uterine metalloproteinase, Matrix metalloproteinase-7, MMP-7, Matrin, MPSL1, PUMP-1, MMP7.

Matrix metalloproteinase-7 (MMP-7), also known as matrilysin and PUMP, is an enzyme that cleaves various substrates such as collagen types IV and X, elastin, fibronectin, gelatin, laminin, and proteoglycans. MMP-7 is structurally different from other members of the stromelysin family as it is encoded by a unique gene and lacks the hemopexin-like domain. It is the smallest MMP, consisting of a pro-peptide domain and a catalytic domain. MMP-7 is initially secreted as a 28 kDa proenzyme, which can be activated in vitro by organomercurials and trypsin and in vivo by MMP-3 to generate an 18 kDa active MMP-7 enzyme. Upon activation, MMP-7 can activate pro-MMP-1 and pro-MMP-9 but not pro-MMP-2. MMP-7 is expressed in various tissues and has been found in elevated levels in cycling endometrium, colorectal cancers and adenomas, hepatocellular carcinomas, rectal carcinomas, and approximately 50% of gliomas.

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  • Sku: PSB-enz-271-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Matrix Metalloproteinase-7, Active is a member of the matrix metalloproteinase family, which are enzymes that play a role in the breakdown of extracellular matrix proteins. This particular enzyme has a molecular weight of approximately 28 kDa and is involved in tissue remodeling and wound healing processes. Recombinant Human Matrix Metalloproteinase-7, Active is commonly used in research and drug development due to its ability to degrade various components of the extracellular matrix.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity
Activity
 The specific activity was found to be 9,100 U/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein contains the following additives 10mM HEPES (pH 7.4), 5mM CaCl2 and 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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MMP7, Active
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