MMP10

Alternative Names: Stromelysin-2, SL-2, MMP-10, Matrix metalloproteinase-10, MMP10, Transin-2, STMY2

MMP10 is a member of the MMP gene cluster on chromosome 11q22.3 and plays a role in activating procollagenase. It is involved in breaking down the extracellular matrix during normal physiological processes like embryonic development, reproduction, and tissue remodeling, as well as in diseases like arthritis and metastasis. Most MMPs are produced as inactive proproteins and become active when cleaved by extracellular proteinases. MMP10's enzyme degrades proteoglycans and fibronectin.

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  • Sku: PSB-enz-764-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Matrix Metalloproteinase 10, belonging to the matrix metalloproteinase (MMP) family, is an enzyme involved in the degradation of extracellular matrix components. With a molecular weight of approximately 67 kDa, MMP-10 plays a role in tissue remodeling and wound healing processes. Its ability to cleave various substrates makes it a key player in maintaining tissue homeostasis and regulating cellular functions. This recombinant protein can be utilized in research studies to investigate its specific functions and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
45.4 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The MMP10 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSFSSFPGM PKWRKTHLTY RIVNYTPDLP RDAVDSAIEK ALKVWEEVTP LTFSRLYEGE ADIMISFAVK EHGDFYSFDG PGHSLAHAYP PGPGLYGDIH FDDDEKWTED ASGTNLFLVA AHELGHSLGL FHSANTEALM YPLYNSFTEL AQFRLSQDDV NGIQSLYGPP PASTEEPLVP TKSVPSGSEM PAKCDPALSF DAISTLRGEY LFFKDRYFWR RSHWNPEPEF HLISAFWPSL PSYLDAAYEV NSRDTVFIFK GNEFWAIRGN EVQAGYPRGI HTLGFPPTIR KIDAAVSDKE KKKTYFFAAD KYWRFDENSQ SMEQGFPRLI ADDFPGVEPK VDAVLQAFGF FYFFSGSSQF EFDPNARMVT HILKSNSWLH C.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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MMP10

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