mMCP2

Alternative Names: Small inducible cytokine A8, SCYA8, CCL8, chemokine (C-C motif) ligand 8, MCP2, Monocyte chemoattractant protein 2, Monocyte chemotactic protein 2, MCP-2, SCYA10, HC14, AB023418, 1810063B20Rik.

Chemokine (C-C motif) ligand 8 (CCL8) is a small cytokine in the CC chemokine family, previously known as monocyte chemotactic protein-2 (MCP-2). The CCL8 protein is initially produced as a precursor with 109 amino acids, which is then cleaved to form mature CCL8 with 75 amino acids. The CCL8 gene consists of 3 exons and is located on chromosome 17q11.2 in humans within a cluster of CC chemokines. MCP-2 acts as a chemoattractant and activator for various immune cells, such as mast cells, eosinophils, basophils, monocytes, T cells, and NK cells. CCL8 exerts its effects by binding to different chemokine receptors on cell surfaces, including CCR1, CCR2B, and CCR5.

  •
  • Sku: PSB-chm-355-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Mouse Monocyte Chemotactic Protein-2 (CCL8) is a chemokine belonging to the CC subfamily. With a molecular weight of approximately 8.6 kDa, this protein plays a role in the recruitment and activation of monocytes, leading to inflammation and immune responses. Recombinant Mouse Monocyte Chemotactic Protein-2 is commonly used in research settings to study chemotaxis and immune cell migration.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg. Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 10-100ng/ml corresponding to a Specific Activity of 10,000-100,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a 0.2µm filtered concentrated (1.0mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

GPDKAPVTCC FHVLKLKIPL RVLKSYERIN NIQCPMEAVV FQTKQGMSLC VDPTQKWVSE YMEILDQKSQ ILQP.

Storage Instruction

Lyophilized MCP-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL8 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CCL8in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
View full details

mMCP2
SUBHEADING

Recently viewed products