mLungkine

Alternative Names: C-X-C motif chemokine 15, Cxcl15, Lungkine, Small-inducible cytokine B15, Scyb15

Mouse Lungkine, also known as CXCL15 (WECHE), is a member of the ELR motif-containing CXC chemokines. It is encoded by a gene located on chromosome 5 and its cDNA produces a 166 amino acid protein, consisting of a 25 amino acid signal peptide and a 141 amino acid mature protein with an unusually long C-terminal tail. This protein is secreted into the bronchoalveolar space and plays a role in directing neutrophils specific to the lungs. Research on Lungkine knockout mice has shown that the protein is essential for guiding neutrophils from the lung tissue into the airspace. It also acts as a chemotactic factor for bone marrow progenitor cells and influences the differentiation of hematopoietic cells. Lungkine transcripts have been identified in adult and fetal lung tissue, with elevated expression levels seen during inflammation. When compared to human ENA-78 and IL-8, mouse Lungkine shares a 35% and 31% amino acid sequence similarity, respectively.

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  • Sku: PSB-chm-286-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Mouse Lungkine (CXCL15) is a chemokine protein that belongs to the CXC subfamily. This protein plays a role in immune response and inflammation by attracting leukocytes to sites of infection or tissue damage. With a weight of approximately 8.3 kDa, Recombinant Mouse Lungkine (CXCL15) is commonly used in research studies to investigate its function in various biological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration of 20-100 ng/ml. The biological activity determined by a chemotaxis bioassay using human neutrophils is in a concentration of 20-100 ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 16.4 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The Lungkine protein was lyophilized from a 0.2µm filtered concentrated solution in PBS pH 7.4 and 0.02% Tween-20.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

QELRCLCIQE HSEFIPLKLI KNIMVIFETI YCNRKEVIAV PKNGSMICLD PDAPWVKATV GPITNRFLPE DLKQKEFPPA MKLLYSVEHE KPLYLSFGRP ENKRIFPFPI RETSRHFADL AHNSDRNFLR DSSEVSLTGS DA.

Storage Instruction

Lyophilized Lungkine although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL15 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Lungkine in sterile 18M-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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mLungkine
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