mLeptin tA PEG

Alternative Names: Not Available

The Recombinant Pegylated Mouse Leptin Triple Antagonist, Pegylated, is a synthetic protein that belongs to the family of pegylated mouse leptin antagonists. With a weight of approximately [insert weight], this compound exhibits potent inhibitory effects on mouse leptin receptors, thereby modulating the signaling pathway associated with leptin. The pegylation process enhances the stability and prolongs the half-life of this antagonist, making it a promising therapeutic option for conditions related to dysregulated leptin signaling.

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  • Sku: PSB-cyt-566-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

The Recombinant Pegylated Mouse Leptin Triple Antagonist, Pegylated, is a synthetic protein that belongs to the family of pegylated mouse leptin antagonists. With a weight of approximately [insert weight], this compound exhibits potent inhibitory effects on mouse leptin receptors, thereby modulating the signaling pathway associated with leptin. The pegylation process enhances the stability and prolongs the half-life of this antagonist, making it a promising therapeutic option for conditions related to dysregulated leptin signaling.

Current Lead Time

7-14 Days

Product Specifications

Species
Mouse
Expression System E. coli
Purity 99.0% by SDS-PAGE
Activity
Leptin Antagonist Triple Mutant Mouse Recombinant half-life in circulation after SC injection was over 20 hours.Leptin Antagonist Triple Mutant Mouse Recombinant is capable of inhibiting leptin-induced proliferation of BAF/3 cells stably transfected with the long form of human leptin receptor. Leptin Antagonist Triple Mutant Mouse Recombinant in vitro activity is 5-6 fold lower than the non-pegylated antagonist, though in vivo it has profound weight gain effect (as compared to the non-pegylated antagonist), resulting mainly from increased food intake.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Contact for Details
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation The Mouse Leptin triple anatagonist was lyophilized from a concentrated (0.65mg/ml) solution with 0.003mM NaHCO3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized Leptin Antagonist Triple Mutant Mouse Recombinant although stable at room temperature for several weeks, should be stored desiccated below -18°C. Upon reconstitution at > 0.1 Leptin mutant mg/ml and up to 2mM and filter sterilization LEP mutant can be stored at 4°C or even room temperature for several weeks making it suitable for long term infusion studies using osmotic pumps. At lower concentration addition of a carrier protein (0.1% HSA or BSA) is suggested. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Leptin Antagonist Triple Mutant Mouse Recombinant in sterile water or sterile 0.4% NaHCO3 adjusted to pH 8-9, not less than 100µg/ml, which can then be further diluted with other aqueous solutions.

References

Not Available

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mLeptin tA PEG

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