mIP10

Alternative Names: Small inducible cytokine B10, CXCL10, 10 kDa, Gamma-IP10, IP-10, chemokine (C-X-C motif) ligand 10, C7, IFI10, INP10, crg-2, mob-1, SCYB10, gIP-10.

Chemokine (C-X-C motif) ligand 10 (CXCL10) is a small cytokine in the CXC chemokine family, secreted by various cell types such as monocytes, endothelial cells, and fibroblasts. CXCL10 has various roles including chemoattraction for monocytes and T cells, T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. The gene for CXCL10 is located on human chromosome 4 among other CXC chemokines. CXCL10 exerts its effects by binding to the cell surface chemokine receptor CXCR3. The three-dimensional crystal structure of CXCL10 has been determined under different conditions to a resolution of up to 1.92A.

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  • Sku: PSB-chm-336-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Mouse IP-10 (CXCL10) is a chemokine belonging to the CXC subfamily. With a molecular weight of approximately 8.7 kDa, this protein plays a key role in immune response by regulating the migration and activation of immune cells. Recombinant Mouse IP-10 is commonly used in research studies to investigate its role in inflammation, autoimmune diseases, and cancer. Its precise mechanism of action and potential therapeutic applications continue to be explored in the scientific community.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 100.0-500.0 ng/ml. Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 100.0-500.0 ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation IP-10 was lyophilized from a 0.2µm filtered concentrated solution in 1×PBS, pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

IPLARTVRCN CIHIDDGPVR MRAIGKLEII PASLSCPRVE IIATMKKNDE QRCLNPESKT IKNLMKAFSQ KRSKRAP.

Storage Instruction

Lyophilized IP-10 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CXCL10 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized IP-10 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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mIP10
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