MIP 3α His

Alternative Names: S Small inducible cytokine A20 precursor, SCYA20, CCL20, Macrophage inflammatory protein 3 alpha, MIP-3-alpha, Liver and activation-regulated chemokine, LARC, Beta chemokine exodus-1, CKb4, ST38, MIP3A, MIP-3a.

CCL-20 is a chemotactic factor that attracts lymphocytes and neutrophils rather than monocytes, while MIP-3 alpha inhibits myeloid progenitor proliferation. These molecules play a role in mucosal lymphoid tissue formation by attracting lymphocytes and dendritic cells. C-terminal processed forms of CCL-20 are equally chemotactically active for leukocytes. CCL-20 also exhibits antibacterial activity against E. coli and S. aureus. Its gene transcription is activated by H. pylori, leading to NF-kappaB activation through intracellular signaling pathways. MIP-3 alpha is involved in lymphocyte trafficking during gastric inflammation in Helicobacter infection. CCL-20 expression recruits CD45R0-positive T cell subsets to the intestinal lamina propria. MIP-3 alpha contributes to pulpal inflammation by recruiting C-C motif Receptor 6-expressing lymphocytes. Additionally, vaginal epithelial cells respond to semen by secreting MIP-3 alpha, which enhances langerhans cell recruitment during HIV transmission.

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  • Sku: PSB-chm-252-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Product Details

Product Description

Recombinant Human Macrophage Inflammatory protein-3 alpha (CCL20), His Tag is a protein belonging to the chemokine family, specifically C-C motif chemokine ligand 20. With a molecular weight of approximately 8.3 kDa, this protein plays a role in the immune response by attracting immune cells to sites of inflammation. The addition of the His Tag allows for easy purification and detection of the protein in research applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 10.3 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The MIP 3a solution (0.25 mg/ml) contains Phosphate Buffered Saline pH7.4 and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MASNFDCCLG YTDRILHPKF IVGFTRQLAN EGCDINAIIF HTKKKLSVCA NPKQTWVKYI VRLLSKKVKN M.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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MIP 3α His
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