MIP 3

Alternative Names: C-C motif chemokine 23, CCL23, Small-inducible cytokine A23, SCYA23, Macrophage inflammatory protein 3, MIP-3, Myeloid progenitor inhibitory factor 1, MPIF-1, CK-beta-8, CKb8, CKB-8, Ckb-8-1.

CCL23 is a chemokine that binds to the CCR1 receptor and is part of a cluster of cytokine genes on chromosome 17. It attracts monocytes, T-lymphocytes, and neutrophils, but not activated lymphocytes, and inhibits the formation of bone marrow myeloid immature progenitors. It is mainly found in lung and liver tissue, as well as in bone marrow, placenta, and some myeloid cell lines. Alternative splicing of the CCL23 gene produces two mRNA isoforms, CK?8 and CK?81. The CK?8 isoform is processed into a shorter and more active variant. MIP-3 may contribute to the progression of certain cancer cells by activating ErbB2 tyrosine kinase and promoting angiogenesis through MMP-2 expression.

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  • Sku: PSB-chm-358-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Macrophage Inflammatory protein-3 (CCL23) is a chemokine belonging to the CC subfamily. It plays a role in the recruitment and activation of monocytes, dendritic cells, and lymphocytes in the immune response. With a molecular weight of approximately 8.7 kDa, CCL23 is involved in inflammatory processes and has been implicated in various diseases such as asthma, rheumatoid arthritis, and cancer. Its function in regulating immune cell trafficking makes it a valuable target for therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 Determined by its ability to chemoattract human T cell population using a concentration range of 10-50ng/ml corresponding to a Specific Activity of 20,000-100,000IU/mg. Determined by its ability to chemoattract human T cell population using a concentration range of 10-50ng/ml corresponding to a Specific Activity of 20,000-100,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 11.3 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Filtered (0.2µm) and lyophilized from a concentrated (1mg/ml) solution in 20mM PB, pH 7.4, 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

RVTKDAETEF MMSKLPLENP VLLDRFHATS ADCCISYTPR SIPCSLLESYFETNSECSKP GVIFLTKKGR RFCANPSDKQ VQVCMRMLKL DTRIKTRKN.

Storage Instruction

Lyophilized MIP-3 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL23 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized MIP-3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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MIP 3
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