MIP 1a, His

Alternative Names: Small inducible cytokine A3, SCYA3, chemokine (C-C motif) ligand 3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, MIP1A, Tonsillar lymphocyte LD78 alpha protein, LD78ALPHA, G0/G1 switch regulatory protein 19-1, G0S19-1, G0S19-1 protein, SIS-beta, PAT 464.1.

Macrophage Inflammatory Proteins (MIP) are a type of chemotactic cytokines called chemokines. In humans, there are two forms, MIP-1a (CCL3) and MIP-1b (CCL4), produced by macrophages in response to bacterial endotoxins. These proteins stimulate granulocytes, leading to acute inflammation. They also trigger the production of other inflammatory cytokines like IL-1, IL-6, and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are located on human chromosome 17.

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  • Sku: PSB-chm-347-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
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Product Details

Product Description

Recombinant Human Macrophage Inflammatory protein-1 alpha (CCL3), His Tag is a protein belonging to the chemokine family. It plays a role in inflammation and immune response regulation. This protein has a molecular weight of approximately 8.3 kDa. Recombinant Human Macrophage Inflammatory protein-1 alpha (CCL3), His Tag is commonly used in research settings for studying chemokine signaling pathways and inflammatory processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90.0 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 10.0 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation MIP-1a protein solution (0.25mg/ml) containing 10mM Sodium Citrate buffer (pH 3.5) and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQVCADPSEEWVQ KYVSDLELSA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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MIP 1a, His
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