MIP 1a

Alternative Names: Small inducible cytokine A3, SCYA3, chemokine (C-C motif) ligand 3, CCL3, Macrophage inflammatory protein 1-alpha, MIP-1-alpha, MIP1A, Tonsillar lymphocyte LD78 alpha protein, LD78ALPHA, G0/G1 switch regulatory protein 19-1, G0S19-1, G0S19-1 protein, SIS-beta, PAT 464.1.

Macrophage Inflammatory Proteins (MIP) are chemotactic cytokines belonging to the chemokine family. In humans, MIP-1a and MIP-1b are known as CCL3 and CCL4, respectively. These proteins are produced by macrophages in response to bacterial endotoxins and can activate granulocytes, leading to acute inflammation. Additionally, they stimulate the production of other pro-inflammatory cytokines like IL-1, IL-6, and TNF-a from fibroblasts and macrophages. The genes for CCL3 and CCL4 are located on human chromosome 17.

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  • Sku: PSB-chm-233-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Macrophage Inflammatory protein-1 alpha (CCL3) is a chemokine belonging to the CC subfamily. With a molecular weight of approximately 8 kDa, CCL3 plays a role in the regulation of inflammatory responses by attracting and activating monocytes, T cells, and NK cells to sites of infection or tissue damage. This chemokine is involved in the recruitment and activation of immune cells, contributing to the body's defense mechanisms against pathogens and foreign invaders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 The Activity is calculated by the ability of chemo-attraction of Human monocytes using 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg. The Activity is calculated by the ability of chemo-attraction of Human monocytes using 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from 0.55 mg/ml solution containing no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be, Ala-Ser-Leu-Ala-Ala.

Storage Instruction

Lyophilized MIP-1a although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL3 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Macrophage Inflammatory Protein-1a in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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MIP 1a
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