mEotaxin

Alternative Names: Small inducible cytokine A11, SCYA11, CCL11, Eosinophil chemotactic protein, chemokine (C-C motif) ligand 11

CCL11, also known as eotaxin, is a small cytokine that belongs to the CC chemokine family. It plays a role in allergic responses by recruiting eosinophils through chemotaxis. CCL11 binds to chemokine receptors CCR2, CCR3, and CCR5. The human gene for CCL11, scya11, is located on chromosome 17 and is encoded on three exons.

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  • Sku: PSB-chm-308-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Mouse Eotaxin (CCL11) is a chemokine protein belonging to the CC chemokine family. This protein plays a role in recruiting eosinophils to sites of inflammation and is involved in the regulation of allergic responses. With a molecular weight of approximately 8.8 kDa, Recombinant Mouse Eotaxin is commonly used in research studies to investigate its role in inflammatory processes and immune responses.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 The Biological activity was determined by measuring the dose dependent phosphorylation of ERK1 and ERK2 in CCR3 transfected 293 cells. Significant ERK phosphorylation is observed with >100 ng/ml (corresponding to a Specific Activity of 10,000IU/mg) of recombinant mouse eotaxin. The Biological activity was determined by measuring the dose dependent phosphorylation of ERK1 and ERK2 in CCR3 transfected 293 cells. Significant ERK phosphorylation is observed with >100 ng/ml (corresponding to a Specific Activity of 10,000IU/mg) of recombinant mouse eotaxin.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a concentrated (1mg/ml) solution in water containing no additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be His-Pro-Gly-Ser-Ile.

Storage Instruction

Lyophilized Eotaxin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL11 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Eotaxin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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mEotaxin
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