MEC His

Alternative Names: CCK1, Protein CCK1, MEC, SCYA28, Small-inducible cytokine A28, MGC71902, Mucosae-associated epithelial chemokine, CCL28, C-C motif chemokine 28.

CCL28, a small cytokine CC gene, attracts resting CD4 or CD8 T cells and eosinophils by binding to chemokine receptors CCR3 and CCR10. It plays a role in maintaining the health of extracutaneous epithelial tissues and contributes to mucosal immunity during HIV exposure and infection, as well as in the development of inflammatory skin diseases. Human CCL28 cDNA codes for a 127 amino acid precursor protein that is processed into a 105 amino acid mature protein. The gene is highly conserved between humans and mice, with 83% amino acid identity. CCL28 shows similarity to CCL27/CTACK and is expressed primarily in colon and lung tissues by epithelial cells.

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  • Sku: PSB-chm-366-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Mucosae-Associated Epithelial Chemokine (CCL28) His Tag is a protein belonging to the chemokine family, which plays a key role in immune system regulation and inflammation. This protein has a molecular weight of approximately 11.6 kDa and is commonly used in research and pharmaceutical applications for its chemotactic properties. Recombinant Human Mucosae-Associated Epithelial Chemokine (CCL28) His Tag is a valuable tool for studying immune responses and developing therapeutic interventions for various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CCL28 protein contains 10mM Sodium Citrate pH3.5 and 10% Glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MILPIASSCC TEVSHHISRR LLERVNMCRI QRADGDCDLA AVILHVKRRR ICVSPHNHTV KQWMKVQAAK KNGKGNVCHR KKHHGKRNSN RAHQGKHETY GHKTPY.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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MEC His
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