MEC

Alternative Names: CCK1, Protein CCK1, MEC, SCYA28, Small-inducible cytokine A28, CCL28, C-C motif chemokine 28, Mucosae-associated epithelial chemokine, MGC71902

CCL28, a member of the small cytokine CC gene subfamily, exhibits chemotactic activity for resting CD4 and CD8 T cells, eosinophils, and binds to chemokine receptors CCR3 and CCR10. It plays a role in the physiology of extracutaneous epithelial tissues, mucosal immunity in HIV exposure, and the pathogenesis of inflammatory skin diseases. Human CCL28 cDNA codes for a 127 amino acid precursor protein with a 22 amino acid signal peptide that is cleaved to produce a 105 amino acid mature protein. It shares 83% amino acid identity with mouse CCL28 and is most similar to CCL27/CTACK. Expression of CCL28 RNA is highest in normal and pathologic colon and is produced by epithelial cells. Additionally, CCL28 RNA is found in normal and asthmatic lung tissues.

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  • Sku: PSB-chm-353-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Mucosae-Associated Epithelial Chemokine (CCL28) is a chemokine protein that belongs to the CC subfamily. It plays a role in the immune response by attracting immune cells to mucosal tissues. This protein has a molecular weight of approximately 9 kDa and is involved in regulating inflammation and immune cell migration in various tissues. CCL28 is a promising target for research in the field of immunology and inflammatory diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 97.0% by SDS-PAGE
Activity
 Determined by its ability to chemoattract human lymphocytes using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg. Determined by its ability to chemoattract human lymphocytes using a concentration range of 1-10ng/ml corresponding to a Specific Activity of 100,000-1,000,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a concentrated (1mg/ml) solution in water containing 20mM PBS and 150mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

SEAILPIASS CCTEVSHHIS RRLLERVNMC RIQRADGDCD LAAVILHVKR RRICVSPHNH TVKQWMKVQA AKKNGKGNVC HRKKHHGKRN SNRAHQGKHE TYGHKTPY.

Storage Instruction

Lyophilized CCL28 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CCL28 should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CCL28 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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MEC
SUBHEADING

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