MDH1

Alternative Names: Cytosolic malate dehydrogenase, EC 1.1.1.37, Malate dehydrogenase cytoplasmic, MDHA, MDH-s, MDH1, MGC:1375, MOR2

Malate dehydrogenase (EC1.1.1.37) is an enzyme involved in the citric acid cycle that converts malate to oxaloacetate using NAD+. This reaction is reversible. Malate dehydrogenase is distinct from malic enzyme, which uses NADPH to convert pyruvate. In addition to its role in the citric acid cycle, malate dehydrogenase plays a part in gluconeogenesis, the process of synthesizing glucose from smaller molecules. Pyruvate in the mitochondria is converted to oxaloacetate by pyruvate carboxylase. Malate dehydrogenase then reduces oxaloacetate to malate for transport across the inner mitochondrial membrane. Once in the cytosol, cytosolic malate dehydrogenase oxidizes malate back to oxaloacetate. Finally, phosphoenol-pyruvate carboxy kinase (PEPCK) converts oxaloacetate to phosphoenolpyruvate.

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  • Sku: PSB-enz-273-1000IU
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Malate Dehydrogenase 1 is an enzyme belonging to the malate dehydrogenase family, specifically involved in the conversion of malate to oxaloacetate in the citric acid cycle. This enzyme plays a key role in cellular metabolism by facilitating the transfer of electrons during the oxidation of malate. Recombinant Malate Dehydrogenase 1 has a molecular weight of approximately 35 kDa, making it a crucial component in the regulation of energy production within the cell. Its recombinant form allows for the production of large quantities of this enzyme for research and industrial applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Recombinant
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Each mg of protein contains 0.59mg NaPO4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Lyophilized Malate dehydrogenase although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution MDH1 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Malate dehydrogenase in sterile 18MΩ-cm H2O.

References

Not Available
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MDH1
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