MDC His

Alternative Names: ABCD-1, A-152E5.1, C-C motif chemokine 22, CC chemokine STCP-1, DC/B-CK, MDC, Macrophage-derived chemokine, MGC34554, SCYA22, Small-inducible cytokine A22, Stimulated T-cell chemotactic protein 1.

MDC, a small cytokine in the CC chemokine family, is chemotactic for certain immune cells such as natural killer cells, T lymphocytes, monocytes, and dendritic cells. It interacts with the chemokine receptor CCR4. CCL22 is primarily expressed in macrophages, dendritic cells, thymus, lymph nodes, and certain types of skin conditions like atopic dermatitis and psoriasis. It may play a role in directing activated T lymphocytes to inflamed areas and hindering lung cancer progression. Higher expression levels of CCL22 have been associated with gastric cancer.

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  • Sku: PSB-chm-367-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Macrophage-Derived Chemokine (CCL22) His Tag is a protein belonging to the chemokine family, specifically C-C motif chemokine. It plays a role in immune response and inflammation by attracting monocytes, dendritic cells, and natural killer cells to the site of infection or injury. This protein has a molecular weight of approximately 9.2 kDa and is commonly used in research and pharmaceutical applications for its chemotactic properties.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The MDC protein contains phosphate-buffered Saline (PBS) pH7.4 and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGPYGANMED SVCCRDYVRY RLPLRVVKHF YWTSDSCPRP GVVLLTFRDK EICADPRVPW VKMILNKLSQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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MDC His

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