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mCyclophilin B

Alternative Names: Cyclophilin B, Cyclophilin B, Peptidyl-prolyl cis-trans isomerase B, PPIase B, Rotamase B, S-cyclophilin, SCYLP, CYP-S1.

Cyclophilin B, also referred to as PPIB, is a cyclosporine-binding protein primarily found in the endoplasmic reticulum. It is involved in the secretory pathway and can be released into biological fluids. This protein has the ability to bind to T- and B-lymphocyte cells and may play a role in regulating cyclosporine A-induced immunosuppression.

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  • Sku: PSB-enz-1039-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Mouse Cyclophilin-B is a protein belonging to the cyclophilin family, which is a subgroup of peptidyl-prolyl cis-trans isomerases. This protein plays a role in protein folding and trafficking within the cell. With a molecular weight of approximately 21 kDa, Recombinant Mouse Cyclophilin-B is involved in various cellular processes, including protein-protein interactions and immune responses. Its recombinant form allows for further research and study of its functions and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Mouse
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Specific activity is > 1,000 nmol/min/mg, and is defined as the amount of enzyme that cleaves 1nmole of suc-AAFP-PNA per minute at 37C in Tris–HCl pH 8.0 using chymotrypsin.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 22.7 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Cyclophilin B protein solution (1mg/ml) containing Phosphate Buffered Saline (pH7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMNDKKKG PKVTVKVYFD LQIGDESVGR VVFGLFGKTV PKTVDNFVAL ATGEKGFGYK NSKFHRVIKD FMIQGGDFTR GDGTGGKSIY GERFPDENFK LKHYGPGWVS MANAGKDTNG SQFFITTVKT SWLDGKHVVF GKVLEGMDVV RKVESTKTDSRDKPLKDVII VDSGKIEVEK PFAIAKE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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