mCTSL

Alternative Names: Not Available

Cathepsin-L (CTSL) belongs to the peptidase C1 family and is a lysosomal cysteine proteinase involved in protein breakdown within cells. It is a dimer consisting of heavy and light chains formed from a single protein precursor. CTSL substrates include collagen, elastin, and alpha-1 protease inhibitor, which controls neutrophil elastase activity. CTSL is associated with various pathological processes such as myofibril necrosis, myocardial ischemia, and renal tubular response to proteinuria. Multiple splice variants of CTSL have been identified.

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  • Sku: PSB-enz-944-1µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Mouse Cathepsin-L is a protease enzyme belonging to the cathepsin family, specifically the cysteine protease group. With a molecular weight of approximately 28 kDa, this enzyme plays a key role in protein degradation and tissue remodeling processes within the body. Recombinant Mouse Cathepsin-L is commonly used in research settings to study its enzymatic activity and potential therapeutic applications in various disease states.

Current Lead Time

7-14 Days

Product Specifications

Species
Mouse
Expression System Sf9 - Baculovirus cells
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
36.8 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CTSL protein solution (0.25mg/ml) containing Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

TPKFDQTFSA EWHQWKSTHR RLYGTNEEEW RRAIWEKNMR MIQLHNGEYS NGQHGFSMEM NAFGDMTNEE FRQVVNGYRH QKHKKGRLFQ EPLMLKIPKS VDWREKGCVT PVKNQGQCGS CWAFSASGCL EGQMFLKTGK LISLSEQNLV DCSHAQGNQG CNGGLMDFAF QYIKENGGLD SEESYPYEAK DGSCKYRAEF AVANDTGFVD IPQQEKALMK AVATVGPISV AMDASHPSLQ FYSSGIYYEP NCSSKNLDHG VLLVGYGYEG TDSNKNKYWL VKNSWGSEWG MEGYIKIAKD RDNHCGLATA ASYPVVNLEH HHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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mCTSL

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