mBACE2

Alternative Names: 1110059C24Rik, AEPLC, AI850424, ALP56, Aspartyl protease 1, Asp 1, beta-site APPcleaving enzyme 2, beta-secretase 2, Memapsin-1, Membrane-associated aspartic protease 1, Theta-secretase, BAE2, CDA13, CEAP1, DRAP, ARP1, ASP1, ASP21.

Recombinant Mouse Beta-Secretase 2 is an enzyme belonging to the beta-secretase family, specifically involved in the cleavage of amyloid precursor protein. With a molecular weight of approximately 54 kDa, this protein plays a significant role in the pathogenesis of Alzheimer's disease by catalyzing the initial step in the production of beta-amyloid peptides. The recombinant form of this enzyme is commonly used in research studies to investigate its structure and function, as well as to develop potential therapeutic strategies targeting beta-secretase activity.

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  • Sku: PSB-enz-1188-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Mouse Beta-Secretase 2 is an enzyme belonging to the beta-secretase family, specifically involved in the cleavage of amyloid precursor protein. With a molecular weight of approximately 54 kDa, this protein plays a significant role in the pathogenesis of Alzheimer's disease by catalyzing the initial step in the production of beta-amyloid peptides. The recombinant form of this enzyme is commonly used in research studies to investigate its structure and function, as well as to develop potential therapeutic strategies targeting beta-secretase activity.

Current Lead Time

7-14 Days

Product Specifications

Species
Mouse
Expression System HEK 293
Purity 95.0 by SDS-PAGE
Activity
Specific activity is > 20 pmol/min/ug in which one unit will convert 1.0pmole of Mca-SEVNLDAEFRK(Dnp)RR-NH2 to Mca- Pro-Leu-OH per minute at pH 3.5 at 25C.
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation BACE2(0.25mg/ml) is filtered in 10% (w/v) glycerol and Phosphate-Buffered Saline pH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

AVPALAPAPF TLPLQVARAT NHRASAVPGL GTPELPRADG LALALEPVRA TANFLAMVDN LQGDSGRGYY LEMLIGTPPQ KVQILVDTGS SNFAVAGAPH SYIDTYFDSE SSSTYHSKGF DVTVKYTQGS WTGFVGEDLV TIPKGFNSSF LVNIATIFES ENFFLPGIKW NGILGLAYAA LAKPSSSLET FFDSLVAQAK IPDIFSMQMC GAGLPVAGSG TNGGSLVLGG IEPSLYKGDI WYTPIKEEWY YQIEILKLEI GGQNLNLDCR EYNADKAIVD SGTTLLRLPQ KVFDAVVEAV ARTSLIPEFS DGFWTGAQLA CWTNSETPWA YFPKISIYLR DENASRSFRI TILPQLYIQP MMGAGFNYEC YRFGISSSTN ALVIGATVME GFYVVFDRAQ RRVGFAVSPC AEIEGTTVSE ISGPFSTEDI ASNCVPAQAL NEP HHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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mBACE2

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